BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//NextToU//EN
CALSCALE:GREGORIAN
BEGIN:VEVENT
UID:0ab93c58-c091-4f5a-8926-806bfffafd69@nexttoyou
DTSTAMP:20261106T174834Z
DTSTART:20261119T210000Z
DTEND:20261119T220000Z
SUMMARY:“Choosing the T-cell profession: the mechanisms within” Keynote Ta
 lk
LOCATION:College of Veterinary Medicine at Cornell University Lecture Hall
  5\, 606 Tower Road\, Ithaca
DESCRIPTION:"Choosing the T-cell profession: the mechanisms within"\nDr. E
 llen Rothenberg (Distinguished Professor of Biology\, California Institut
 e of Technology\; A.D. White Professor-at-Large at Cornell)\nThursday\, N
 ovember 19\, 2026\n4:00pm ⋅ Lecture Hall 5\, College of Veterinary Medici
 ne\nOpen to all ⋅ Reception to follow in CVM Atrium.\n\nAn A.D. White Pro
 fessors-at-Large Program keynote public talk. Cosponsored by the Dept. of
  Microbiology and Immunology and the Dept. of Molecular Biology and Genet
 ics.\n\nAbstract: This talk focuses on the way the T-cell program emerges
  from primitive blood cell precursors with both myeloid and lymphoid cell
  developmental potentials. The migration of the multipotent precursors fr
 om bone marrow to the thymus makes T-cell development possible\, as the t
 hymic environment delivers strong Notch pathway signals to the precursor 
 cells until they relinquish alternative potentials and undergo commitment
  to the T-cell lineage. The availability of powerful in vitro culture sys
 tems to mimic the thymus have enabled studies leading to a deep molecular
  analysis of the underlying mechanisms. The cells start with a multipoten
 t precursor chromatin epigenomic state that persists with minimal change 
 as the T cell transcriptional program begins\, even though inherited clos
 ed chromatin measurably holds back the onset of expression of critical T-
 cell genes. However\, as commitment is triggered\, thousands of changes o
 ccur coordinately across the genome\, involving both opening and clos\n\n
 http://next-to-u.app/events/0ab93c58-c091-4f5a-8926-806bfffafd69
URL:http://next-to-u.app/events/0ab93c58-c091-4f5a-8926-806bfffafd69
END:VEVENT
END:VCALENDAR