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UID:4073e843-d605-401c-93c7-7c8ac59bbac3@nexttoyou
DTSTAMP:20261105T154633Z
DTSTART:20261110T210000Z
DTEND:20261110T220000Z
SUMMARY:SCSB Special Seminar with Dr. Aya Ito-Ishida: Cross-species analys
 es reveal conserved cortical network alterations in Rett syndrome
LOCATION:Building 46 46-3002\, Singleton Auditorium\, 43 VASSAR ST\, Cambr
 idge\, MA 02139
DESCRIPTION:Date: Tuesday\, November 10\, 2026\nLocation: 46-3002 (Singlet
 on Auditorium). Please note this talk will not be recorded\nTime: 4:00pm-
 5:00pm ET\n\nSpeaker: Aya Ito-Ishida\, M.D.\, Ph.D.\nAffiliation: Team Di
 rector\, Laboratory for Brain Development and Disorders\, RIKEN Center fo
 r Brain Science\n\nHosts: Dr. Giselle Fernandes\, Dr. Mriganka Sur\n\nTal
 k title: Cross-species analyses reveal conserved cortical network alterat
 ions in Rett syndrome\n\nAbstract: Cortical circuits undergo extensive re
 organization during development to support the emergence of complex cogni
 tive behaviors. Disruption of this process is thought to contribute to ne
 urodevelopmental disorders\, but how genetic alterations reshape large-sc
 ale cortical organization\, how these changes relate to behavioral impair
 ments\, and whether they can be reversed remain poorly understood. Rett s
 yndrome\, a monogenic neurodevelopmental disorder\, provides a unique gen
 etically defined system for linking molecular alterations\, large-scale c
 ircuit dysfunction\, and behavioral consequences. In this talk\, I will p
 resent our recent work combining resting-state fMRI in individuals with R
 ett syndrome and wide-field calcium imaging in mice. Our findings suggest
  a conserved disruption of cortical functional hierarchy that is closely 
 associated with behavioral severity. Furthermore\, we find that this abno
 rmality is reversible following MECP2 reintroduction in mice\, suggesting
  that this approach may provide a cross-species framework for evaluating 
 emergi\n\nhttp://next-to-u.app/events/4073e843-d605-401c-93c7-7c8ac59bbac
 3
URL:http://next-to-u.app/events/4073e843-d605-401c-93c7-7c8ac59bbac3
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