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UID:5d9162b9-d4df-4efb-bc37-17085db901f2@nexttoyou
DTSTAMP:20261105T153018Z
DTSTART:20261105T210000Z
DTEND:20261105T220000Z
SUMMARY:Bioengineering Seminar Series - Dr. Adele Moatti
LOCATION:Benedum Hall 157\, 3700 O'Hara Street\, Pittsburgh\, PA 15261
DESCRIPTION:Dr. Adele Moatti\, Assistant Professor in the Department of Ot
 olaryngology–Head and Neck Surgery at the University of Pittsburgh School
  of Medicine and Adjunct Assistant Professor of Biomedical Engineering at
  Carnegie Mellon University\, will present "Rebuilding the Translational 
 Pipeline for Inner Ear Therapies."\n\nAbstract\n\nA major barrier in inne
 r ear therapeutics is not a single limitation\, but a broken pipeline\, w
 here clinically relevant models\, targeting strategies\, and delivery mec
 hanisms fail to align. Here\, we rebuild this pipeline by integrating com
 plementary translational advances. We establish a porcine model of cochle
 ar synaptopathy that captures key features of human pathology\, enabling 
 meaningful evaluation of therapeutic interventions. In parallel\, we gene
 rate a comprehensive map of AAV expression in the pig inner ear\, providi
 ng a critical bridge between mouse studies and clinically relevant gene t
 herapy design. We further demonstrate that extracellular vesicles (EVs) c
 an be harnessed to enhance safe local AAV delivery\, improving transducti
 on efficiency while reducing immune responses. Finally\, we uncover an un
 expected biological lever of drug delivery: sensory-driven formulation ef
 fects. We show that modulation of taste receptor signaling can extend dru
 g retention within the inner ear\, revealing a new axis for therapeutic c
 ontrol. Together\, these advances shift the paradigm from isolated soluti
 ons to an integrated\, translatable framework for inner ear gene and d\n\
 nhttp://next-to-u.app/events/5d9162b9-d4df-4efb-bc37-17085db901f2
URL:http://next-to-u.app/events/5d9162b9-d4df-4efb-bc37-17085db901f2
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