BEGIN:VCALENDAR VERSION:2.0 PRODID:-//NextToU//EN CALSCALE:GREGORIAN BEGIN:VEVENT UID:6bd184fc-be1a-44a1-8f56-64470a0e5ff9@nexttoyou DTSTAMP:20261106T174846Z DTSTART:20261112T210000Z DTEND:20261112T220000Z SUMMARY:Bioengineering Seminar Series - Dr. Anne Andrews LOCATION:Benedum Hall 157\, 3700 O'Hara Street\, Pittsburgh\, PA 15261 DESCRIPTION:Dr. Anne Andrews\, Professor of Psychiatry & Biobehavioral Sci ences\, Chemistry & Biochemistry\, and Bioengineering at University of Ca lifornia\, Los Angeles\, will present "Advancing Neurotransmitter Monitor ing."\n\nAbstract\n\nOur research advances methods for in vivo neurotrans mitter monitoring with high temporal\, spatial\, and chemical resolution. Building on Ralph Adams' pioneering work\, we coupled online microdialys is with HPLC and electrochemical detection to enable rapid\, near-real-ti me multiplexed neurotransmitter monitoring in behaving animals. For direc t sampling\, we developed rapid-pulse voltammetry coupled to machine lear ning. To address waveform design challenges\, we developed a Bayesian opt imization workflow to efficiently identify high-information waveforms. Ou r background-inclusive rapid-pulse voltammetry enables simultaneous in vi vo monitoring of dopamine and serotonin\, for example. We provide open-so urce software\, including SeroWare—an end-to-end platform for data acquis ition and analysis—that supports a wide range of voltammetry formats\, fr om pulses to scans. These tools are applicable to a range of electrochemi cal analytes\, forming a pipeline for optimizing multi-analyte detection and machine-learning analysis. To extend to non-electrochemically active neurotransmitters and hormones\, we designed DNA aptamer-based biosensors coupled with field-effect transistors for implantable and wearable monit oring. We investigate the effects of transgenerational stress and are d\n \nhttp://next-to-u.app/events/6bd184fc-be1a-44a1-8f56-64470a0e5ff9 URL:http://next-to-u.app/events/6bd184fc-be1a-44a1-8f56-64470a0e5ff9 END:VEVENT END:VCALENDAR