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UID:6f9114c0-060f-4383-b1a5-9757835fe7d7@nexttoyou
DTSTAMP:20261105T161021Z
DTSTART:20261110T153000Z
DTEND:20261110T163000Z
SUMMARY:Doctoral Dissertation Defense | Jennifer Chavez
LOCATION:AHC5 - Academic Health Center 5 401\, 11200 SW 8th ST\, Academic 
 Health Center 5\, Miami\, Florida 33199
DESCRIPTION:UNIVERSITY GRADUATE SCHOOL BULLETIN\nANNOUNCEMENT\n\nFlorida I
 nternational University\nUniversity Graduate School\n\nDoctoral Dissertat
 ion Defense\n\nAbstract\nProbing the Proteome: Depressive Symptoms\, Infl
 ammation & Mitochondrial Perturbations in Acute HIV Infection\n\nby\nJenn
 ifer Vanessa Chavez\n\nThere is ample evidence that HIV-associated pathop
 hysiologic alterations fuel neuropsychiatric comorbidities.\nDuring acute
  HIV infection (AHI) damage to the gut-associated lymphoid tissue causes 
 translocation of microbial\nproducts\, including lipopolysaccharides\, an
 d drives gut-immune dysfunction. Even though antiretroviral therapy (ART)
 \nsuppresses viral replication\, it fails to completely restore gut barri
 er integrity and normalize plasma immune markers\,\ndriving chronic immun
 e activation and inflammation. This proinflammatory state is made worse b
 y a marked reduction in\nantioxidants and upregulation of ROS and/or reac
 tive nitrogen species\, affecting mitochondrial function. Additionally\,\
 nsubstance use also increases HIV pathogenesis in the central nervous sys
 tem (CNS) despite ART.\nProteomics\, the evaluation of the function and s
 tructure of proteins to understand an organism’s nature\, has been\nlever
 aged to examine HIV-associated outcomes across the lifespan. However\, mu
 ch of the existing literature has focused\non individuals with chronic\, 
 treated HIV infection\, making it challenging to disentangle the biologic
 al processes initiated\nby HIV itself from the compounded effects of chro
 nic infection\,\n\nhttp://next-to-u.app/events/6f9114c0-060f-4383-b1a5-97
 57835fe7d7
URL:http://next-to-u.app/events/6f9114c0-060f-4383-b1a5-9757835fe7d7
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