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UID:7b68b0ba-f0af-4f1e-93b4-05a6f3679c23@nexttoyou
DTSTAMP:20261107T014037Z
DTSTART:20261123T202000Z
DTEND:20261123T212000Z
SUMMARY:Dissertation Defense: Stephanie Frahs
LOCATION:Education Building (EDUC) 109\, 2133 W. Friendship Lane\, Boise\,
  ID 83725
DESCRIPTION:Title: Biomaterials and Biomimetic Models for Musculoskeletal 
 Tissue Repair\n\nProgram: Biomolecular Sciences PhD\n\nCommittee Chair: J
 ulia Oxford\n\nCommittee: Julia Oxford\, Ken Cornell\, Daniel Fologea\n\n
 Abstract: Musculoskeletal tissue repair represents a major therapeutic ch
 allenge due to the complex structural\, biochemical and mechanical hetero
 geneity of musculoskeletal tissues including ligament\, tendon\, cartilag
 e\, and bone. To elucidate the mechanisms governing ECM assembly and tiss
 ue repair\, this research evaluated three biomimetic models targeting dis
 tinct musculoskeletal tissues: fibroblast-collagen hydrogels for ligament
  and tendon scar formation\, three-dimensional (3D) graphene foam (GF) as
  a scaffold for cartilage regeneration\, and freeze-dried decellularized 
 cancellous bone allografts for osteogenic repair.\nFor ligament repair\, 
 culturing fibroblast-collagen hydrogels under stress-free\, biaxial\, and
  uniaxial conditions over three weeks demonstrated that stress-free loadi
 ng induced time-dependent gene expression of early scar markers (Col3a1\,
  TnC)\, whereas biaxial stress optimized matrix protein accumulation (typ
 e III collagen\, decorin). Thus\, initial culturing under biaxial stress 
 best replicates native mechanical boundary constraints during early scar 
 modeling.\nFor cartilage tissue engineering studies\, functionalizing 3D 
 GF scaffolds with fibronectin (FN) altered cellular responses in prechond
 rocytes. Molecular dynamics simulations identified non-covalent bonding v
 ia ar\n\nhttp://next-to-u.app/events/7b68b0ba-f0af-4f1e-93b4-05a6f3679c23
URL:http://next-to-u.app/events/7b68b0ba-f0af-4f1e-93b4-05a6f3679c23
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