BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//NextToU//EN
CALSCALE:GREGORIAN
BEGIN:VEVENT
UID:893f3f45-ee50-42a1-90de-b686c5930166@nexttoyou
DTSTAMP:20261105T160226Z
DTSTART:20261109T183000Z
DTEND:20261109T193000Z
SUMMARY:Doctoral Dissertation Defense | Said Salehe
LOCATION:AHC5 - Academic Health Center 5 500\, 11200 SW 8th ST\, Academic 
 Health Center 5\, Miami\, Florida 33199
DESCRIPTION:UNIVERSITY GRADUATE SCHOOL BULLETIN\nANNOUNCEMENT\n\nFlorida I
 nternational University\nUniversity Graduate School\n\nDoctoral Dissertat
 ion Defense\n\nAbstract\n\nNoncanonical Roles of DRP1 in Brain Aging and 
 Parkinson’s Disease: Lipid Droplets\, Neuroinflammation\, and\nSynaptic R
 emodeling\n\nBy\nSaid S. Salehe\n\nBrain aging and neurodegenerative diso
 rders such as Parkinson's disease (PD) share several hallmarks\,\nincludi
 ng chronic neuroinflammation\, pathological lipid-droplet (LD) accumulati
 on\, and synaptic alterations.\nHowever\, the upstream regulators of thes
 e processes remain poorly defined. This dissertation identifies noncanoni
 cal\nroles for dynamin-related protein 1 (DRP1)\, best known for mediatin
 g mitochondrial fission\, in\nregulating lipid metabolism\, neuroinflamma
 tion\, and synaptic integrity.\nAcross models of aging\, lipopolysacchari
 de (LPS)-induced inflammation\, and α-synuclein\noverexpression\, LD accu
 mulation was greater in microglia than in other cell types. Microglial DR
 P1 abundance\ncorrelated positively with LD burden\, whereas partial DRP1
  knockout or pharmacological inhibition reduced\nLD accumulation and infl
 ammatory gene expression. Mechanistically\, DRP1 deficiency suppressed LP
 Sinduced\nlong-chain acyl-CoA synthetase 1 (Acsl1) expression via NF-κB s
 ignaling. Inhibiting NF-κB or ACSL\nactivity likewise decreased LD accumu
 lation in primary microglia. In human postmortem substantia nigra\,\nACSL
 1 expression and PLIN2-positive LD burden were elevated relative to non-P
 D tissue\, with increa\n\nhttp://next-to-u.app/events/893f3f45-ee50-42a1-
 90de-b686c5930166
URL:http://next-to-u.app/events/893f3f45-ee50-42a1-90de-b686c5930166
END:VEVENT
END:VCALENDAR