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UID:8bfee757-1696-4bdd-8fd1-0398ac6cf149@nexttoyou
DTSTAMP:20261106T173140Z
DTSTART:20261106T195500Z
DTEND:20261106T211000Z
SUMMARY:BME7900 Seminar: Dr. Wilbur A. Lam (Emory)
LOCATION:Weill Hall 226
DESCRIPTION:Engineering Microsystems to Investigate the Mechanobiology of 
 Blood in Health and Disease\n\nBlood is fundamentally mechanical in natur
 e\, comprising diverse cellular subtypes navigating complex hydrodynamic 
 environments. Perturbations in these biomechanical dynamics directly driv
 e hematologic and cardiovascular pathologies. This presentation highlight
 s our lab's multidisciplinary approach—combining microfluidics\, biophysi
 cs\, and hematology—to bridge microscale mechanobiology with clinical dia
 gnostic and therapeutic translation.\n\nFirst\, we explore how bioenginee
 red microfluidic systems model pathological mechanobiolohy. In sickle cel
 l disease\, we describe how reduced erythrocyte deformability in and of i
 tself causes aberrant cell margination toward microvascular walls. Comput
 ational simulations and endothelialized microfluidic systems pioneered by
  our laboratory reveal that marginated\, stiffened red blood cells induce
  localized wall shear stress fluctuations\, triggering pro-inflammatory e
 ndothelial gene expression via mechanotransduction—a mechanism distinct f
 rom the canonical microvascular obstruction that oversimplifies sickle ce
 ll pathophysiology.\n\nNext\, using advanced hydrogel-based microvasculat
 ure-on-a-chip platforms\, we investigate long-term vascular dysfunction\,
  endothelial barrier permeability\, and thrombo-inflammation over weeks t
 o months\, demonstrating how targeted therapeutics like tPA facilitate cl
 ot resolution to restore endothelial function after thrombosis. Our l\n\n
 http://next-to-u.app/events/8bfee757-1696-4bdd-8fd1-0398ac6cf149
URL:http://next-to-u.app/events/8bfee757-1696-4bdd-8fd1-0398ac6cf149
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