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UID:9dfc12c7-3aa5-4599-bf9a-937dba13bc0d@nexttoyou
DTSTAMP:20261105T153252Z
DTSTART:20261106T153000Z
DTEND:20261106T163000Z
SUMMARY:Biomedical Engineering Seminar Series
LOCATION:Ammon Pinizzotto Biopharmaceutical Innovation Center 140 AB\, 590
  Avenue 1743\, Newark\, DE 19713
DESCRIPTION:Megan L. McCain\, Ph.D.\n\nDepartment of Stem Cell Biology and
  Regenerative Medicine\, Keck School of Medicine Alfred E. Mann Departmen
 t of Biomedical Engineering\, Viterbi School of Engineering University of
  Southern California (USC)\n\nSEMINAR: Engineering Microphysiological Sys
 tems to Decode Mechanobiological Drivers of Cardiac and Uterine Disorders
 \n\nThe heart and the uterus are both muscular organs\, and their physiol
 ogical function depends on their ability to dynamically sense and adapt t
 o mechanical forces. In many diseases and disorders\, maladaptive respons
 es to mechanical forces contribute to pathological remodeling and tissue 
 dysfunction. Microphysiological systems are powerful platforms for system
 atically investigating how mechanical forces regulate human tissue physio
 logy and pathophysiology. In this talk\, I will describe how we use micro
 physiological systems to identify the effects of mechanical stretch on hu
 man cardiac and uterine muscle in disease-relevant contexts. We found tha
 t cardiomyocytes derived from patients with hypoplastic left heart syndro
 me\, a congenital heart defect\, exhibit pathological responses to cyclic
  stretch\, a stimulus that normally promotes cardiomyocyte maturation. We
  also found that static stretch\, a defining feature of late stages of pr
 egnancy\, modulates the oxytocin sensitivity of human uterine smooth musc
 le cells\, with implications for understanding mechanisms of preterm labo
 r. Together\, these studies demonstrate how microphysiological systems\n\
 nhttp://next-to-u.app/events/9dfc12c7-3aa5-4599-bf9a-937dba13bc0d
URL:http://next-to-u.app/events/9dfc12c7-3aa5-4599-bf9a-937dba13bc0d
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