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UID:a3a45137-3449-4c00-8aed-55eb98c8bdd7@nexttoyou
DTSTAMP:20261106T172701Z
DTSTART:20261112T170000Z
DTEND:20261112T180000Z
SUMMARY:Nonsense-Mediated mRNA Decay in Human Health and Disease: Reframin
 g the Role of FMRP in Fragile X Syndrome
DESCRIPTION:This Translational Science Grand Rounds presentation will focu
 s on understanding the importance of nonsense-mediated mRNA decay (NMD) t
 o normal and disease-associated mRNA metabolism\, predicting which mutati
 ons in an mRNA will trigger NMD\, and appreciating the complicated web of
  co- and post-transcriptional gene control.\n\nNMD is always "on" in all 
 of our cells\, although with different efficiencies. While we initially d
 iscovered NMD through RNA-centric studies of inherited hemolytic anemias\
 , we now know that NMD eliminates one-third of mRNAs that we routinely ma
 ke by mistake\, and NMD efficiency is altered by cells as a means to adap
 t to various stressors. Mechanistic aspects of NMD will be overviewed bef
 ore transitioning to how our continued studies of NMD serendipitously led
  us to elucidate RNA metabolic abnormalities in Fragile X Syndrome.\n\nPr
 esented by Lynne E. Maquat\, PhD\, J. Lowell Orbison Endowed Professor\, 
 Department of Biochemistry and Biophysics\, Oncology\, and Pediatrics\, U
 niversity of Rochester Medicine. This Translational Science Grand Rounds 
 event is sponsored and organized by the Clinical and Translational Scienc
 e Institute.\n\nLynne E. Maquat\, PhD\, is the J. Lowell Orbison Endowed 
 Chair and Professor of Biochemistry & Biophysics who holds concomitant ap
 pointments in Pediatrics and in Oncology\, Founding Director of the Cente
 r for RNA Biology\, and Founding Chair of Graduates Working in Science at
  the University of Rochester.\n\nAfter obtaining her PhD in Biochemistry 
 f\n\nhttp://next-to-u.app/events/a3a45137-3449-4c00-8aed-55eb98c8bdd7
URL:http://next-to-u.app/events/a3a45137-3449-4c00-8aed-55eb98c8bdd7
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