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UID:b037155f-c463-422b-908a-d9a07f5bf990@nexttoyou
DTSTAMP:20261106T173835Z
DTSTART:20261112T193000Z
DTEND:20261112T203000Z
SUMMARY:Professor Andrea D. Merg (University of California\, Merced) Semin
 ar
LOCATION:Chevron Science Center 152\, 219 Parkman Avenue\, Pittsburgh\, PA
  15260
DESCRIPTION:Title: From the Bottom-Up: Engineering Nanoscale Architectures
  from De Novo Peptide Building Blocks\n\nAbstract: While proteins serve a
 s nature’s building block of choice for constructing complex and function
 al architectures\, peptides represent an attractive\, synthetically acces
 sible alternative. Peptides can mimic several features of proteins\, incl
 uding common protein folding motifs (e.g.\, alpha helices\, coiled coils\
 , collagen triple helices\, etc.) and various biological functions (e.g.\
 , cell signaling and hormone regulation). Moreover\, due to their relativ
 ely short sequence length\, peptides are amenable to a myriad of bioorgan
 ic chemical transformations\, which affords the ability to incorporate a 
 broad range of nonnatural moieties into the sequence design. These featur
 es position peptides as robust\, sequence-programmable building blocks fo
 r constructing bioinspired materials with properties and functions that c
 an extend beyond the proteome. However\, the advantages afforded by utili
 zing peptides as molecular building blocks\, also play a role in their li
 mitations. Due to their truncated sequence length\, peptides cannot encod
 e the same level of structural complexity that can be packaged within pro
 teins. As such\, peptides are often relegated to forming lower dimensiona
 l\, less complex structures via relatively non-specific and non-programma
 ble intermolecular interactions. In this talk\, I will discuss how our la
 b is expanding the peptide building block design in order to unlock new\n
 \nhttp://next-to-u.app/events/b037155f-c463-422b-908a-d9a07f5bf990
URL:http://next-to-u.app/events/b037155f-c463-422b-908a-d9a07f5bf990
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