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UID:cbd5b8ae-5dba-4ef2-9bfd-2e173ca92f44@nexttoyou
DTSTAMP:20261105T150928Z
DTSTART:20261106T190000Z
DTEND:20261106T200000Z
SUMMARY:InspireME Seminar - Sean Howard\, Ph. D. (Boise State University)
LOCATION:Micron Center for Materials Research (MCMR) 106\, 1435 W Universi
 ty Dr\, Boise\, ID 83706
DESCRIPTION:Mission V.I.B.E.S.: The process of sending a science payload t
 o space\n\nAged individuals and astronauts experience bone loss despite r
 igorous physical activity. Bone mechanoresponse is partly regulated by me
 senchymal stem cells (MSCs) that respond to mechanical challenges. To inv
 estigate if microgravity affects the mechanoresponse of MSCs in bone\, we
  developed 3D Bone Marrow Analogs (BMAs) to be maintained in hardware abo
 ard the International Space Station (ISS). To create a BMA model\, we gen
 erated two idealized 3D trabecular lattices mimicking young (25%) or old 
 (13%) trabecular bone volumes and filled them with hydrogel-encapsulated 
 primary bone marrow MSCs to mimic bone marrow. These BMAs were then treat
 ed with low-intensity vibrations (LIV) to determine if these mechanical s
 ignals can overcome the loss of gravity in space to stimulate osteogenesi
 s. A scheduled 21-day experiment aboard the ISS (Spx34 mission\, May 2026
 ) includes two CubeLab units with or without the LIV bioreactor. BMAs wil
 l receive 0.7 g\, 90 Hz LIV twice daily for 20 minutes\, separated by a 2
 -hour rest period\, and compared to non-LIV and ground controls under ost
 eogenic differentiation media. BMAs from each group will be analyzed for 
 osteogenic differentiation using RNA-seq and immunostaining. This experim
 ent will determine whether MSCs maintain a mechanoresponse during a 21-da
 y spaceflight and provide a platform for studying bone marrow mechanobiol
 ogy and bone-related diseases aboard the ISS.\n\nThe InspireM\n\nhttp://n
 ext-to-u.app/events/cbd5b8ae-5dba-4ef2-9bfd-2e173ca92f44
URL:http://next-to-u.app/events/cbd5b8ae-5dba-4ef2-9bfd-2e173ca92f44
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