Biomolecular Sciences Seminar Series: Dr. Gunes Uzer
- When
- Wednesday, November 11, 20263:00 PM – 4:15 PM MSTAdd to calendarGoogle Calendar
- Where
- Education Building (EDUC) 1092133 W. Friendship Lane, Boise, ID 83725Open in Maps
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About
Biomolecular Sciences Seminar Series
Dr. Gunes Uzer, Boise State University
Title: Mechanobiology of Stem Cells in Health and Disease
Abstract: Sensation of mechanical environment is critical in directing cellular function and, in the case of stem cells, regulating lineage selection. This seminar will focus on the mesenchymal stem cells in the bone marrow that provide regenerative capacity by replacing and reinforcing the skeleton at load bearing sites. The ability of mesenchymal stem cells to respond to mechanical cues generated during functional loading is critical for this capacity. I will discuss my laboratory’s findings on how mechanical coupling of nucleus with the cytoskeleton contributes to mesenchymal stem cell mechanosignaling, fate selection as well as applying lessons learned as strategies to alleviate age related stem cell exhaustion and developing models to study mechanoregulation in aging bone-marrow. During the talk, I will further highlight current data-driven image analysis and macro/nano scale cellular mechanics studies towards cellular mechano-omics for basic science and clinical applications.