Neuroscience First Year Presentation: Brodie Woodall

About

Please join us

Thursday, November 19, 2026

4:30pm – 5:00pm CST

CRA 12.110

for a First Year Presentation by

Brodie Woodall

University of Texas at Dallas

Eukaryotic Initiation Factor 2A Regulates Pain Hypersensitivity in Experimental

Autoimmune Encephalomyelitis, a Model of Multiple Sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the nervous system characterized by neurodegeneration, demyelination, and inflammation. Over half of MS patients experience neuropathic pain that is poorly treated. Translation regulation is known to be a contributor to pain pathogenesis, specifically through the Integrated Stress Response (ISR) and eIF2A-driven translation of stress-resistant genes. We show that eIF2A is elevated in post-mortem human Dorsal Root Ganglia (DRG) samples and further utilize a mouse model of MS known as Experimental Autoimmune Encephalomyelitis (EAE) to assess the role of eIF2A-driven translation in the EAE-induced pain phenotype. Our data establishes a translational approach to uncovering mechanisms of pain in MS and identifies potential avenues for therapeutic developments.

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