Semiconductor Nanolaser Particles for Highly Multiplexed Single-Cell Tracking and Sensing
- When
- Thursday, November 5, 20263:00 PM – 4:00 PM CSTAdd to calendarGoogle Calendar
- Where
- OconnorOpen in Maps
- Hosted by
- Materials Science & NanoEngineering
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About
Featuring:
Sangyeon (Fred) Cho, Ph.D., Assistant Professor, Department of Bioengineering, CPRIT Rising Star Scholar, Rice University
Website: (link below)
Abstract:
Dynamic cellular heterogeneity shapes cancer progression, immune responses, and therapeutic outcomes, yet tracking individual cell histories remains a major challenge. Conventional fluorescent labels are limited by broad emission spectra and spectral overlap, while DNA barcodes require destructive readout.
In this seminar, I will introduce nanolaser particles, intracellular optical probes engineered from semiconductor gain materials and optical microcavities that generate ultra-narrow laser emission, enabling thousands of unique optical identities. I will discuss semiconductor materials design, scalable nanofabrication, and Laser Particle Stimulated Emission (LASE) microscopy for long-term single-cell tracking and sensing in vitro and in vivo. I will also highlight emerging applications in cellular sensing. Finally, I will present our recent development of plasmonic nanolasers measuring approximately 115 nm, demonstrating extreme optical confinement and opening new opportunities for miniaturized coherent light sources and nanoscale biological barcoding and sensing.